Dan and Jodi’s Breyanzi story

Dan and Jodi holding AGLCA flags on a boat
Dan standing on a bridge on vacation
Dan and Jodi taking a selfie while on vacation

When I heard about CAR T cell therapy, I had a lot of faith and a lot of hope.

—Jodi, wife and care partner

An unforgettable day

One summer day, Jodi wheeled her husband Dan into a Boston hospital to receive CAR T cell therapy. They didn’t know what to expect. But they did know that diffuse large B-cell lymphoma (DLBCL) was spreading through Dan’s body, and they had to do something.

A feeling washed over the couple as they settled in for their stay. It was going to be OK. Later, their nurse would write something on the whiteboard in Dan’s room.

“Day One”—two words Dan and Jodi will never forget.

“Danny and I have known each other for 30 years, and we’ve been married for nine,” Jodi says. “But that day truly was our day one.”

Dan and Jodi taking a selfie on a bridge

Three months to live

A few years earlier, Dan worked in construction and Jodi in human resources. Life was good. They had bought a boat—something cheap, just to see if they liked it. They did.

Though Boston had been home for years, the couple started dreaming of a bigger boat and a longer adventure.

Dan had always been healthy. Ever since he started building homes as a teenager, Dan had never even taken a sick day—until a mysterious lump on his neck led to a diagnosis of DLBCL.

The diagnosis didn’t slow him down at first. For 3 years, Dan and Jodi watched and waited. But then Dan started feeling tired and short of breath.

Tests revealed a tumor wrapped around his small intestine. Dan started chemotherapy at their community hospital. Six rounds was the plan, but after 3, scans showed the chemo wasn’t working.

Dan walking at the beach

At that point, our only hope was getting into a trial.

After consulting more specialists, Dan started a more aggressive chemo and planned for a stem cell transplant. The doctors had already harvested Dan’s stem cells and were ready to go forward with a transplant when a scan showed his tumor was still growing.

The doctors gave Dan 2 or 3 months to live.

“At that point, our only hope was getting into a trial,” Jodi says. At the time, she worked for a company that did genomic testing, so they tested Dan’s tumor. It looked like immunotherapy could be an option, and the couple was referred to a doctor at a major healthcare center in Boston.

A promising treatment option

Because Dan had received at least 2 previous treatments that didn't work or stopped working, the specialist told Jodi and Dan about a trial for a CAR T cell therapy, now approved as Breyanzi, which would be made from Dan’s T cells (a type of white blood cell) to help fight the cancer.

“I had never heard of CAR T cell therapy, but after the doctor explained it, I said, ‘That’s what I’d like to have,’” Dan says. “I liked the idea that you’re using your own reprogrammed white blood cells to help fight the cancer.”

Dan asked to get on the hospital’s waiting list. His doctor replied, “You already are.”

Dan looking out across the water while on a boat

I liked the idea that you’re using your own white blood cells to help fight the cancer.

In the meantime, Dan and Jodi considered the risks. They learned about the potential side effects of Breyanzi that are life-threatening and can lead to death, including cytokine release syndrome and neurologic toxicity, as well as other common side effects, including fever, low white or red blood cells, severe diarrhea, or severe nausea. But Dan and Jodi felt Breyanzi would be the right option for him.

See additional Breyanzi Important Safety Information.

“In my mind, what was my choice? I knew I might not make it if we didn’t do something. We had to go for it,” Dan says.

Fortunately, he didn’t have to wait long. He rose to the top of the list, and soon, Dan’s T cells were collected through a process called leukapheresis. For 4 weeks, Jodi and Dan went to the hospital 3 to 4 days a week for transfusions, infusions, and salvage chemo—trying to keep Dan alive so he could receive his CAR T cell therapy.

By this time, the always healthy Dan could only walk 12 to 15 feet before having to rest for 10 minutes. Jodi was worried, but Dan, as always, put a smile on her face.

“Danny has this amazing attitude, and I think we laughed every day throughout the horrible journey,” she says. “We were able to find some good in every single day.”

For Dan, it was just his way of life.

“You’ve got to keep a positive attitude,” he says.

Dan receiving treatment for DLBCL

Day One: Infusion day

One day, they got the call: “Your T cells are coming.”

After 3 days of tests, bloodwork, scans, and lymphodepletion chemo to make sure he was ready, Dan was admitted to the hospital for his CAR T cell treatment.

“The nurse came into my room and spent hours setting up every possible contingency. When the doctor finally came in, the infusion took less than a half hour,” Dan says.

As the CAR T cells entered his body, Dan and Jodi held on to hope, the words “Day One” written on the whiteboard nearby.

In the days following his infusion, Dan remained in the hospital for monitoring and treatment for Breyanzi side effects. Ten days later, he managed to walk from the hospital to the car. He had to remain close to the hospital for at least 4 weeks, for continued monitoring for potentially serious side effects, but 1 month later, PET scans revealed that Dan was in remission. Because of the risk of cytokine release syndrome, neurologic toxicity, and other side effects, patients like Dan must remain close to where they received treatment for at least 4 weeks after the infusion for side effect monitoring.

“When we saw the scans, everyone was so happy for Danny, which was incredible,” Jodi says. “I was crying my eyes out in gratitude.”

While the scans showed that Dan was in remission, it does not mean he's cancer-free. Dan continues to be monitored for possible disease recurrence and long-term side effects from CAR T cell therapy.

The great loop

Dan finally bought his dream boat—a 43-foot power catamaran. He and Jodi spent any chance they could familiarizing themselves with the boat and the East Coast. Then, after retiring, they took off on their dream adventure, the Great Loop.

They started in Florida, sailing up the East Coast to the Hudson River and Erie Canal, through the Great Lakes, down the Illinois and Mississippi rivers, across the Gulf, and back to Florida.

10,000 miles, countless memories, and friendships to last a lifetime.

Jodi taking a selfie with Dan on a boat

Dan had always wanted to do this. We know how lucky we are. We say it every single day.

—Jodi, wife and care partner

Now that they’ve returned home, their days are filled with family, friends—and their young granddaughter. They continue living each day to the fullest.

Like each day is Day One.

Dan and Jodi taking a selfie while on vacation

What appeals to me about CAR T cell therapy is using your own cells to fight the cancer.

See more stories from others treated with Breyanzi

Bill’s Story

Bill learned mental and physical toughness at a young age—a resilience he’d carry into his fight with DLBCL. When the cancer he’d managed for 10 years took a turn for the worse, Bill’s positivity intersected with a great medical team and treatment with Breyanzi.

Nick’s Story

Nick was facing the fight of his life when he discovered a new treatment for DLBCL.

David’s Story

David received Breyanzi to help battle his cancer after being diagnosed with DLBCL and failing multiple treatments.

Important Safety Information

What is the most important information I should know about BREYANZI?

BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:

  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • severe nausea, vomiting, diarrhea
  • fast or irregular heartbeat
  • dizziness/lightheadedness
  • severe fatigue or weakness

Important Safety Information

What is the most important information I should know about BREYANZI?

BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:

  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • severe nausea, vomiting, diarrhea
  • fast or irregular heartbeat
  • dizziness/lightheadedness
  • severe fatigue or weakness

It is important that you tell your healthcare providers that you have received BREYANZI and to show them your BREYANZI Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

How will I receive BREYANZI?

  • BREYANZI is made from your own white blood cells, so your blood will be collected by a process called leukapheresis.
  • It takes about 3-4 weeks from the time your cells are received at the manufacturing site and are available to be shipped back to your healthcare provider, but the time may vary.
  • Before you get BREYANZI, you will get 3 days of chemotherapy to prepare your body.
  • When your BREYANZI is ready, your healthcare provider will give it to you through a catheter placed into your vein. BREYANZI is given as infusions of 2 different cell types.
    • You will receive infusions of one cell type, immediately followed by the other cell type.
    • The time for infusion will vary, but will usually be less than 15 minutes for each of the 2 cell types.
  • During the first week, you will be monitored daily by the facility where you received your treatment.
  • You should plan to stay close to this location for at least 4 weeks after getting BREYANZI. Your healthcare provider will check to see that your treatment is working and help you with any side effects that may occur.
  • You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving BREYANZI?

  • Do not drive, operate heavy machinery, or do other activities that could be dangerous if you are not mentally alert, for at least 8 weeks after you get BREYANZI. This is because the treatment can cause temporary memory and coordination problems, including sleepiness, confusion, dizziness, and seizures.
  • Do not donate blood, organs, tissues, or cells for transplantation.

What are the possible or reasonably likely side effects of BREYANZI?

The most common side effects of BREYANZI are:

  • fatigue
  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • difficulty speaking or slurred speech
  • severe nausea, vomiting, diarrhea
  • headache
  • dizziness/lightheadedness
  • fast or irregular heartbeat
  • swelling

BREYANZI can increase the risk of life-threatening infections that may lead to death. Tell your healthcare provider right away if you develop fever, chills, or any signs or symptoms of an infection.

BREYANZI can lower one or more types of your blood cells (red blood cells, white blood cells, or platelets). After treatment, your healthcare provider will test your blood to check for this. Tell your healthcare provider right away if you get a fever, are feeling tired, or have bruising or bleeding.

Having BREYANZI in your blood may cause a false-positive HIV test result by some commercial tests.

These are not all the possible side effects of BREYANZI. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNINGS and Medication Guide.


BREYANZI is for the treatment of large B-cell lymphoma in patients when at least 2 previous treatments have not worked or have stopped working. BREYANZI is a medicine made from your own white blood cells; the cells are genetically modified to recognize and attack your lymphoma cells.