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Breyanzi CAR T Cell Treatment Steps

Your treatment with Breyanzi is centered around you

The typical CAR T cell therapy process can take approximately 2 to 3 months of treatment and initial follow-up monitoring

Chart displaying steps of preparing and receiving Breyanzi treatment Chart displaying steps of preparing and receiving Breyanzi treatment

Every person is different, and the time it takes to complete the Breyanzi CAR T cell therapy process may vary. Your healthcare provider will decide if you will need to stay in the hospital, or if you can be discharged, after treatment. You should plan to stay close to the treatment site for at least 4 weeks after treatment. After receiving Breyanzi, you will work with your healthcare team to determine a long-term plan that goes beyond the initial 3 months.

Each step of your treatment is important. Your healthcare team will be by your side to help along the way. Don't hesitate to ask as many questions as you need to, so you feel more knowledgeable about the treatment process.

Breyanzi treatment process

You will work closely with your healthcare team during each step of treatment. Because of the risk of side effects that are life-threatening and can lead to death, Breyanzi is only available at authorized treatment centers and must be infused by specially trained healthcare teams.

Breyanzi CAR T Cell Treatment Apheresis

Blood collection

Your white blood cells will be collected through a process called apheresis (sometimes called leukapheresis)

Your blood is drawn, and then each of the components is separated into groups. Your T cells are removed, but the other parts of your blood are returned to your body.

Apheresis can be done in 1 day and usually takes 2 to 6 hours.

Breyanzi CAR T Cell Treatment Manufacturing

Creating Breyanzi

Your T cells will be sent to a CAR T cell manufacturing site

While at the manufacturing site, chimeric antigen receptors (CARs) are added to your T cells. This creates Breyanzi CAR T cells that are unique to you. It takes about 3 to 4 weeks to make Breyanzi CAR T cells, starting from the time your cells are received at the manufacturing site to when they are available to be shipped back to your healthcare team. However, everyone’s cells are different, and process times may vary.

While your CAR T cells are being made, your healthcare provider may also recommend other treatments.

Breyanzi CAR T Cell Treatment Low-dose Chemotherapy

Low-dose chemotherapy

Before your Breyanzi infusion, you’ll receive 3 days of chemotherapy.

This is called lymphodepleting chemotherapy, and it will help prepare your body for Breyanzi.

Breyanzi CAR T Cell Treatment Infusion

How you’ll receive Breyanzi

You’ll receive Breyanzi as infusions of 2 different cell types

Breyanzi is given as infusions of 2 different cell types. These infusions are given one after the other, and each takes less than 15 minutes to infuse, but times may vary.

These infusions will be given at an authorized treatment center by a specially trained healthcare team. Your healthcare provider will decide if you will need to stay in the hospital or if you can be discharged, after treatment. You should plan to stay close to the treatment site for at least 4 weeks after treatment.

Breyanzi CAR T Cell Treatment Initial Monitoring

Initial follow-up monitoring

You’ll be closely monitored for side effects following your Breyanzi infusion

During the first week, you will be monitored daily by the facility where you received your treatment.

You should plan to stay close to this location for at least 4 weeks after getting Breyanzi. Your healthcare provider will check to see that your treatment is working and help you with any side effects that may occur.

You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.

Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

Breyanzi CAR T Cell Therapy Healthcare Team

Long-term follow-up

You’ll follow up with your healthcare team

You and your healthcare team will work together to track your progress, response to treatment, and watch out for side effects. Additional scans and blood tests may also be needed.

Learn about Breyanzi treatment outcomes and side effects seen in the clinical study.

SEE THE RESULTS
READ MORE +

Important Safety Information

What is the most important information I should know about BREYANZI?

BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:

  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • severe nausea, vomiting, diarrhea
  • fast or irregular heartbeat
  • dizziness/lightheadedness
  • severe fatigue or weakness

Important Safety Information

What is the most important information I should know about BREYANZI?

BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:

  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • severe nausea, vomiting, diarrhea
  • fast or irregular heartbeat
  • dizziness/lightheadedness
  • severe fatigue or weakness

It is important that you tell your healthcare providers that you have received BREYANZI and to show them your BREYANZI Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

How will I receive BREYANZI?

  • BREYANZI is made from your own white blood cells, so your blood will be collected by a process called leukapheresis.
  • It takes about 3-4 weeks from the time your cells are received at the manufacturing site and are available to be shipped back to your healthcare provider, but the time may vary.
  • Before you get BREYANZI, you will get 3 days of chemotherapy to prepare your body.
  • When your BREYANZI is ready, your healthcare provider will give it to you through a catheter placed into your vein. BREYANZI is given as infusions of 2 different cell types.
    • You will receive infusions of one cell type, immediately followed by the other cell type.
    • The time for infusion will vary, but will usually be less than 15 minutes for each of the 2 cell types.
  • During the first week, you will be monitored daily by the facility where you received your treatment.
  • You should plan to stay close to this location for at least 4 weeks after getting BREYANZI. Your healthcare provider will check to see that your treatment is working and help you with any side effects that may occur.
  • You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
  • Your healthcare provider will want to do blood tests to follow your progress. It is important that you have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving BREYANZI?

  • Do not drive, operate heavy machinery, or do other activities that could be dangerous if you are not mentally alert, for at least 8 weeks after you get BREYANZI. This is because the treatment can cause temporary memory and coordination problems, including sleepiness, confusion, dizziness, and seizures.
  • Do not donate blood, organs, tissues, or cells for transplantation.

What are the possible or reasonably likely side effects of BREYANZI?

The most common side effects of BREYANZI are:

  • fatigue
  • difficulty breathing
  • fever (100.4°F/38°C or higher)
  • chills/shaking chills
  • confusion
  • difficulty speaking or slurred speech
  • severe nausea, vomiting, diarrhea
  • headache
  • dizziness/lightheadedness
  • fast or irregular heartbeat
  • swelling

BREYANZI can increase the risk of life-threatening infections that may lead to death. Tell your healthcare provider right away if you develop fever, chills, or any signs or symptoms of an infection.

BREYANZI can lower one or more types of your blood cells (red blood cells, white blood cells, or platelets). After treatment, your healthcare provider will test your blood to check for this. Tell your healthcare provider right away if you get a fever, are feeling tired, or have bruising or bleeding.

Having BREYANZI in your blood may cause a false-positive HIV test result by some commercial tests.

These are not all the possible side effects of BREYANZI. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNINGS and Medication Guide.

Indication

BREYANZI is for the treatment of large B-cell lymphoma in patients when at least 2 previous treatments have not worked or have stopped working. BREYANZI is a medicine made from your own white blood cells; the cells are genetically modified to recognize and attack your lymphoma cells.