BREYANZI is a prescription medicine used to treat large B cell lymphoma, a type of non-Hodgkin lymphoma, when:
- your first treatment has not worked or your cancer returned within a year of your first treatment OR...Read more
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See links below for full Prescribing Information, including Boxed WARNINGS and Medication Guide.
*The treatment process includes blood collection, chimeric antigen receptor (CAR) T cell creation, administration, and side-effect monitoring.
Not actual patients or care partner.
Please see full Prescribing Information, including Boxed WARNINGS and
Medication Guide.
Indication
BREYANZI is a prescription medicine used to treat large B cell lymphoma, a type of non-Hodgkin lymphoma, when:
- your first treatment has not worked or your cancer returned within a year of your first treatment OR
- your first treatment has not worked or your cancer returned after the first treatment, and you are not eligible for hematopoietic stem cell transplantation because of medical conditions or age OR
- two or more kinds of treatment have not worked or stopped working.
BREYANZI is different than other cancer medicines because it is made from your own white blood cells, which have been genetically modified to recognize and attack your lymphoma cells.
Important Safety Information
What is the most important information I should know about BREYANZI?
BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:
difficulty breathing
fever (100.4°F/38°C or higher)
chills/shaking chills
confusion
severe nausea, vomiting, diarrhea
fast or irregular heartbeat
dizziness/lightheadedness
severe fatigue or weakness
It is important that you tell your healthcare providers that you have received BREYANZI
and to show them your BREYANZI Patient Wallet Card. Your healthcare provider may
give you other medicines to treat your side effects.
Full Prescribing Information, including Boxed WARNINGS and Medication Guide
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Before getting BREYANZI, tell your healthcare provider about all your medical problems, including if you have or have had:
Neurologic problems
(such as seizures, stroke, or memory loss)Lung or breathing problems
Heart problems
Liver problems
Kidney problems
A recent or active infection
Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
How will I receive BREYANZI?
BREYANZI is made from your own white blood cells, so your blood will be collected by a process called leukapheresis.
It takes about 3-4 weeks from the time your cells are received at the manufacturing site and are available to be shipped back to your healthcare provider, but the time may vary.
Before you get BREYANZI, you will get 3 days of chemotherapy to prepare your body.
When your BREYANZI is ready, your healthcare provider will give it to you through a catheter placed into your vein. BREYANZI is given as infusions of 2 different cell types.
You will receive infusions of one cell type, immediately followed by the other cell type.
The time for infusion will vary, but will usually be less than 15 minutes for each of the 2 cell types.
During the first week, you will be monitored daily by the facility where you received your treatment.
You should plan to stay close to this location for at least 4 weeks after getting BREYANZI. Your healthcare provider will check to see that your treatment is working and help you with any side effects that may occur.
You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
Your healthcare provider will want to do blood tests to follow your progress. It is important that you have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.
What should I avoid after receiving BREYANZI?
Do not drive, operate heavy machinery, or do other activities that could be dangerous if you are not mentally alert, for at least 8 weeks after you get BREYANZI. This is because the treatment can cause temporary memory and coordination problems, including sleepiness, confusion, dizziness, and seizures.
Do not donate blood, organs, tissues, or cells for transplantation.
What are the possible or reasonably likely side effects of BREYANZI?
The most common side effects of BREYANZI are:
fatigue
difficulty breathing
fever (100.4°F/38°C or higher)
chills/shaking chills
confusion
difficulty speaking or slurred speech
severe nausea, vomiting, diarrhea
headache
dizziness/lightheadedness
fast or irregular heartbeat
swelling
BREYANZI can increase the risk of life-threatening infections that may lead to death. Tell your healthcare provider right away if you develop fever, chills, or any signs or symptoms of an infection.
BREYANZI can lower one or more types of your blood cells (red blood cells, white blood cells, or platelets). After treatment, your healthcare provider will test your blood to check for this. Tell your healthcare provider right away if you get a fever, are feeling tired, or have bruising or bleeding.
Having BREYANZI in your blood may cause a false-positive HIV test result by some commercial tests.
These are not all the possible side effects of BREYANZI. Call your doctor for medical advice about side effects. For more information, go to BREYANZI.com or call
1-888-805-4555. You may report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see full Prescribing Information, including Boxed WARNINGS and Medication Guide.
The typical CAR T cell therapy process can take approximately 2 to 3 months of treatment and initial follow-up monitoring
The typical CAR T cell therapy process can take approximately 2 to 3 months of treatment and initial follow-up monitoring
Each step of your treatment is important. Your healthcare team will help you throughout treatment and monitoring. They can answer any questions you may have about Breyanzi.
Everyone is different, and the time it takes to complete the Breyanzi CAR T cell therapy process may vary.
Breyanzi treatment process
Blood collection
Blood collection
Your white blood cells will be collected through a process called apheresis (sometimes called leukapheresis)
Your blood is drawn and the components are separated into groups. Your T cells are collected and the other parts of your blood are returned back into your body.
Apheresis can be done in 1 day and usually takes 2 to 6 hours.
Creating Breyanzi
Creating Breyanzi
Your T cells will be sent to a manufacturing site
While at the manufacturing site, chimeric antigen receptors (CARs) are added to your T cells to make the Breyanzi CAR T cells that are unique to you.
During this time, you may receive other treatments for the cancer.
Low-dose chemotherapy
Low-dose chemotherapy
Before your Breyanzi infusion, you’ll receive low-dose chemotherapy
You’ll receive 3 days of a low-dose of chemotherapy, called lymphodepleting chemotherapy, to help prepare your body for Breyanzi.
Receiving Breyanzi
Receiving Breyanzi
You'll receive Breyanzi as infusions of 2 different cell types
Breyanzi is given as infusions of 2 different cell types. These infusions are given one after the other, and each takes less than 15 minutes to infuse, but times may vary.
Breyanzi will be given at an authorized treatment center by a specially trained healthcare team. Your healthcare provider will decide if you need to stay in the hospital or if you can be discharged after treatment.
Monitoring
Monitoring
You'll be closely monitored for side effects following your Breyanzi infusion
During the first week, you will be monitored daily by the facility where you received Breyanzi. Plan to stay close to this location for at least 4 weeks after infusion.
You may be hospitalized for side effects and your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave.
Long-term monitoring
Your healthcare provider will want to do blood tests to follow your progress. It is important that you have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.
Because of the risk of side effects that are life-threatening and can lead to death, Breyanzi is only available at authorized treatment centers and must be infused by specially trained healthcare teams.