ASTRID FOUND A DIFFERENT KIND OF TREATMENT—VIDEO TRANSCRIPT

[Footage of Astrid pushing a child in a stroller, with her husband and dog behind her. Pictures of her childhood and graduation are shown. Text on screen says “Astrid”]

Astrid: My name is Astrid. I am married, I have a little boy. I was born and raised in Mexico and moved to the US when I was in my teens. And then I'm also a PA, a physician assistant working in pediatric surgery.

[On-screen text: Astrid is an actual patient who was compensated for her time.]

[Footage of Astrid seated and talking alternates with pictures and videos of her and her family]

Astrid: So I was in school, and I started having itching all over my body. I did go to the doctor and I told her, and she just kind of said, “Oh, it’s all stress and I think you’re fine.” And then things just started getting worse from there.

[On-screen text: Aurora
Astrid’s sister]

[Footage of Astrid and her sister, Aurora, video chatting]

Aurora: The day before she went to the hospital, Astrid actually called me, and she was telling me that she felt like there was a huge pressure on her chest.

[On-screen text: Daniel
Astrid’s husband
Daniel and Aurora are family members and were compensated for their time.]

Daniel: The trigger that sent us to go, that sent Astrid to go to the ER was really, really strong chest pain.

Astrid: But I was in the emergency room, kind of clenched like this, and so they immediately sent me back, did testing, got my labs done. I was just kind of like, “Oh, this is overkill, I’m sure it’s nothing.” And then the doctor comes in and she just kind of sits down and just says, “You don't have a clot in your lung, but you have a mass in your chest.” 11 by 12 by 8, a pretty big-size mass. And I just remember thinking in my head the size of a ruler and just 10 centimeters, “How does that fit in here?” The next day I had my biopsy done. And then we got the results…non-Hodgkins large B-cell lymphoma.

Daniel: Very, very scary. A lot of uncertainty that you don’t want in your life.

Astrid: I think we both just like, broke down, hearing that. And then a week later, I started chemotherapy.

[On-screen text: First-line treatment]

[Images of IV pump and Astrid in a hospital bed, undergoing chemotherapy]

Astrid: For six cycles, I was admitted for a whole week—just chemotherapy running 24/7.

Aurora: Chemo was…absolutely brutal.

Astrid: It was the nausea. The initial nausea was…horrible. I was doubled over in bed in a fetal position because there was nothing that could make the nausea better.

Aurora: She was all bloated, she couldn’t move very well. I don’t know, I was just shocked to see that someone so close to me was going through that. 

[Picture of Astrid laying with her dog on the couch after chemotherapy]

Astrid: And then by the sixth cycle, the scan was still lighting up.

Daniel: I remember the doctor’s face when he told us that he’s sorry, that it came back and it was a very clear signal. What you thought was going to happen, what you hoped was going to happen is not going to happen.

Astrid: So at that point it was either a stem cell transplant. Or, my doctor mentioned there was this new treatment, clinical trial, called CAR T-cell therapy.

[On-screen text: CAR T=chimeric antigen receptor T-cell therapy]

Astrid: So when it was explained to me, CAR T required a little bit of chemotherapy to kind of wipe out your bone marrow a little bit and then it was using your own immune cells to fight the cancer cells. Immune cells that were taken to a lab, and then they engineer them, or they change them so that it can recognize the cancer cells, but also, it also recognizes your normal cell, your normal immune cells. They put them back in you, and then they recognize the cancer and fight it. I liked the idea that it was like my own immune system and it just felt a little bit more targeted.

[On-screen text: The TRANSFORM clinical trial studied a second-line treatment called Breyanzi in patients whose first treatment didn’t work or whose cancer came back. Breyanzi was compared to the standard therapy, which included transplant.]

[On-screen text: CAR T-treatment with Breyanzi^® (lisocabtagene maraleucel)
We will hear more from Astrid after this brief, important safety information.]

Voiceover: Indications

BREYANZI is a prescription medicine used to treat a type of non-Hodgkin lymphoma:

• Large B cell lymphoma, when:
  • your first treatment has not worked or your cancer returned within a year of your first treatment, OR
  • your first treatment has not worked or your cancer returned after the first treatment, and you are not eligible for hematopoietic stem cell transplantation because of medical conditions or age, OR
  • two or more kinds of treatment have not worked or stopped working.

BREYANZI is different than other cancer medicines because it is made from your own white blood cells, which have been genetically modified to recognize and attack your lymphoma cells.

Important Safety Information

What is the most important information I should know about BREYANZI?

BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:

• difficulty breathing
• fever (100.4°F/38°C or higher)
• chills/shaking chills
• confusion
• severe nausea, vomiting, diarrhea
• fast or irregular heartbeat
• dizziness/lightheadedness
• severe fatigue or weakness

These are not all the possible side effects of BREYANZI. Call your doctor for medical advice about side effects. For more information, go to BREYANZI.com or call 1-888-805-4555. You may report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNINGS and Medication Guide.

Astrid: So, after that I got the CAR T cells injected in through my IV.

[On-screen text: Treatment experiences, including side effects, may vary. Please see the important Safety information in this video for the serious side effects that can occur with Breyanzi.]

[Image of Astrid in a hospital bed receiving Breyanzi]

Astrid: I did experience a lot of chest pain initially. But then my side effects really were mostly a lot of fatigue… after that 10 days in the hospital, they saw that I was doing okay so they sent me home.

[On-screen text: Astrid’s Results]

Astrid: The 30-day scan, or four weeks after the infusion, they rescanned me. And then at that point, the scan had showed significant progress.

Aurora: It was very positive, definitely after the first scan, when things started to look much better, we were all very happy. 

Astrid: And so my doctor said “You know, usually, we see the biggest response after the first 30 days, but I think at the three-month mark is when we really see if this is going to stay or not."

Daniel: A few months later when we went back in to do the scan and we were told “remission”; it was just the greatest sense of relief you could imagine. I mean it was...

[Image of Astrid jumping in the air; Image of Astrid hugging her dog and holding a mug that says “In Remission”; Image of Astrid and Daniel together]

Astrid: Oh my gosh, it was a lot of excitement.

Daniel: I was just… you melt in a way. A certain part of you just feels like it’s been released.

[Images of Astrid with her family; footage of Astrid baking cookies and at the playground with her family]

Astrid: I learned that you can't really plan life and I sort of take this approach: I try to stay in the now. And I prioritize family and quality time and friends because at the end of the day, that's what matters.

[On-screen text: Talk to your doctor to find out if BREYANZI^® is right for you]

Voiceover:

Important Safety Information

What is the most important information I should know about BREYANZI?

BREYANZI may cause side effects that are life-threatening and can lead to death. Call your healthcare provider or get emergency help right away if you get any of the following:

• difficulty breathing
• fever (100.4°F/38°C or higher)
• chills/shaking chills
• confusion
• severe nausea, vomiting, diarrhea
• fast or irregular heartbeat
• dizziness/lightheadedness
• severe fatigue or weakness

It is important that you tell your healthcare providers that you have received BREYANZI and to show them your BREYANZI Patient Wallet Card. Your healthcare provider may give you other medicines to treat your side effects.

Before getting BREYANZI, tell your healthcare provider about all your medical problems, including if you have or have had:

• Neurologic problems (such as seizures, stroke, or memory loss)
• Lung or breathing problems
• Heart problems
• Liver problems
• Kidney problems
• A recent or active infection

Tell your healthcare provider about all the medications you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will I receive BREYANZI?

• BREYANZI is made from your own white blood cells, so your blood will be collected by a process called leukapheresis.
• It takes about 3-4 weeks from the time your cells are received at the manufacturing site and are available to be shipped back to your healthcare provider, but the time may vary.
• Before you get BREYANZI, you will get 3 days of chemotherapy to prepare your body.
• When your BREYANZI is ready, your healthcare provider will give it to you through a catheter placed into your vein (intravenous infusion). BREYANZI is given as infusions of 2 different cell types.
  • You will receive infusions of one cell type, immediately followed by the other cell type.
  • The time for infusion will vary but will usually be less than 15 minutes for each of the 2 cell types.
• During the first week after infusion, you will be monitored daily by the facility where you received your treatment.
• You should plan to stay within 2 hours of the location where you received your treatment for at least 4 weeks after getting BREYANZI. Your healthcare provider will check to see that your treatment is working and help you with any side effects that may occur.
• You may be hospitalized for side effects. Your healthcare provider will discharge you if your side effects are under control, and it is safe for you to leave the hospital.
• Your healthcare provider will want to do blood tests to follow your progress. It is important that you do have your blood tested. If you miss an appointment, call your healthcare provider as soon as possible to reschedule.

What should I avoid after receiving BREYANZI?

• Do not drive, operate heavy machinery, or do other activities that could be dangerous if you are not mentally alert, for at least 8 weeks after you get BREYANZI. This is because the treatment can cause temporary memory and coordination problems, including sleepiness, confusion, dizziness, and seizures.
• Do not donate blood, organs, tissues, or cells for transplantation.

What are the possible or reasonably likely side effects of BREYANZI?

The most common side effects of BREYANZI are:

• fatigue
• difficulty breathing
• fever (100.4°F/38°C or higher)
• chills/shaking chills
• confusion
• difficulty speaking or slurred speech
• severe nausea, vomiting, diarrhea
• headache
• dizziness/lightheadedness
• fast or irregular heartbeat
• swelling
• low blood pressure
• muscle pain

BREYANZI can increase the risk of life-threatening infections that may lead to death. Tell your healthcare provider right away if you develop fever, chills, or any signs or symptoms of an infection.

BREYANZI can lower one or more types of your blood cells (red blood cells, white blood cells, or platelets). After treatment, your healthcare provider will test your blood to check for this. Tell your healthcare provider right away if you get a fever, are feeling tired, or have bruising or bleeding.

BREYANZI may increase your risk of getting cancers including certain types of blood cancers. Your healthcare provider should monitor you for this.

Having BREYANZI in your blood may cause a false-positive HIV test result by some commercial tests.

These are not all the possible side effects of BREYANZI. Call your doctor for medical advice about side effects. For more information, go to BREYANZI.com or call 1-888-805-4555. You may report side effects to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Boxed WARNINGS and Medication Guide.

[Breyanzi logo, BMS logo]
©2025 Juno Therapeutics, Inc., a Bristol-Myers Squibb Company. All Rights Reserved.
BREYANZI and the related logo are trademarks of Juno Therapeutics, Inc. a Bristol-Myers Squibb Company.
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